MuleSoft is a software company headquartered in San Francisco, California that provides integration software for connecting applications, data and devices. Started in 2006, the company's Anypoint Platform of integration products is designed to tie together software as a service (SaaS) and on-premises software.

The company originally provided middleware and messaging, and later expanded to provide an integration platform as a service (iPaaS) approach for companies. MuleSoft provides APIhub, a directory that is designed to function as a social network for developers to share updates and information, currently covering more than 13,000 APIs. For consumers and developers, it provides a catalogue of APIs along with an interactive development environment for running basic queries. For API providers, it offers a publishing platform and various tools to automatically generate API documentation. MuleSoft develops Mule ESB, an integration platform for connecting enterprise applications on-premises and to the cloud, designed to eliminate the need for custom point-to-point integration code.

Ross Mason and Dave Rosenberg founded MuleSource in 2006. The company changed the name to MuleSoft in 2009. In April 2013, the startup announced $37 million in Series E financing in a round led by New Enterprise Associates, with participation from new strategic investor Salesforce.com, and existing investors Hummer Winblad Venture Partners, Morgenthaler Ventures, Lightspeed Venture Partners, SAP Ventures and Bay Partners. The round brought MuleSoft's total financing to $81 million.

In April 2013, MuleSoft acquired ProgrammableWeb, a website used by developers to help build web, mobile and other connected applications through APIs.

In 2016, MuleSoft was ranked #20 on the Forbes Cloud 100 list.

In February 2017, the company filed for an IPO and began trading on the New York Stock Exchange on March 17, 2017.. The stock rose more than 45% on its first day of trading.