Chemical Bank is a Michigan-based bank headquartered in Midland, Michigan. It is the wholly owned subsidiary of Chemical Financial Corporation, and has 249 offices. It is Michigan's largest bank.

Chemical Financial Corporation ("Chemical") is the largest banking company headquartered and operating branch offices in Michigan. Chemical operates through its subsidiary bank, Chemical Bank with 249 banking centers in Michigan, Northeast Ohio, and Northern Indiana. At June 30, 2017, Chemical had total assets of $18.78 billion. Chemical Financial Corporation's common stock trades on The NASDAQ Stock Market under the symbol CHFC and is one of the issues comprising The NASDAQ Global Select Market.

The current CEO of Chemical Financial Corporation is David T. Provost. Chemical Bank has received an "outstanding" CRA rating from the Federal Reserve Bank of Chicago.

On March 11, 2014, the boards of directors of Chemical Financial Corporation (Nasdaq: CHFC), the holding company for Chemical Bank, and Northwestern Bancorp, Inc., the holding company for Northwestern Bank, announced the execution of a definitive agreement for Chemical Financial Corporation ("Chemical") to partner with Northwestern Bancorp, Inc. (“Northwestern"). The acquisition was expected to complete sometime in the third quarter. With the partnership with Northwestern and its 25 branches across 11 northwestern Michigan counties it is anticipated that Chemical Bank will have the largest retail branch delivery network (ranked by number of branch locations) outside of the Detroit MSA of any financial institution operating in Michigan. The acquisition of Northwestern was completed on October 31, 2014.

In January 2016 it was announced that Chemical Bank had acquired Talmer Bancorp of Troy, Michigan, subject to regulatory approval. The merger was completed on August 31, 2016.

Chemical State Savings Bank was founded in 1917 and the bank celebrated its 100th anniversary in 2017.

The headquarters of Chemical Bank was the site of Tony Chebatoris' infamous bank robbery in 1937, which ultimately ended in Chebatoris being the only man receiving the death penalty in the state of Michigan.

Chemical Bank and Trust Company changed its name to Chemical Bank in 1973 to reflect that their trust activities were only one part of the total business.