Susquehanna Bank was a Lancaster, Pennsylvania-based bank which operated over 260 branches in four states including Pennsylvania, Maryland, New Jersey, and West Virginia. Susquehanna Bank's parent company was Susquehanna Bancshares, Inc. (NASDAQ: SUSQ) a regional financial services holding company based in Lititz, Pennsylvania with assets of approximately US$18,000,000,000 and 3,400 employees.

Susquehanna Bank was founded in 1901 as the Farmers National Bank of Lititz. In 1972 this bank changed its name to Farmers First Bank, and beginning in the 1970s it began to acquire other banks in the region, establishing Susquehanna Bancshares as its holding company in 1982 and expanding its reach into the states south of Pennsylvania beginning in the late 1980s. In 2004, Susquehanna Bancshares consolidated its operations into three banks, all using the Susquehanna name. The company has continued to expand, including two large acquisitions in 2008.

In 2008, Susquehanna Bank acquired the naming rights to the Susquehanna Bank Center in Camden, New Jersey.

In 2014, BB&T bank, announced its purchase of Susquehanna Bank as part of a major push into the Mid-Atlantic region. The larger bank was easily able to acquire the much more localized bank. The deal was finalized on August 3, 2015 and all Susquehanna Bank branches were converted to BB&T four months later. Many local communities were discontented with this acquisition by a powerful, yet unfamiliar bank.