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Cyclacel Pharmaceuticals, Inc.
Type
Public (NASDAQ: CYCC)
Industry Biotechnology
Founded 1997
Headquarters Berkeley Heights, New Jersey, U.S.
Key people
Spiro Rombotis, CEO
David P. Lane, Founder
Products Seliciclib (CYC202),
Sapacitabine (CYC682),
Aurora kinase inhibitors (CYC116)
Net income
Decrease US$ 19.7 million (2010)
Number of employees
18 (2011)
Website http://www.cyclacel.com

Cyclacel Pharmaceuticals Inc. is a biotechnology firm based in Dundee, Scotland and Short Hills, New Jersey developing cancer drugs and treatments. Cyclacel was founded in 1996 by Professor David Lane, Merlin Ventures and Cancer Research Campaign Technology with the University of Dundee and the University of Glasgow.

Major shareholders include Goldman Sachs Group, Tang Capital Management, Redmile Group and Ayer Capital Management.

The firm is developing "mechanism-targeted drugs" to help in the fight of cancer, and other serious illness, such as diabetes and HIV.

Cyclacel Pharmaceuticals, Inc. is a biopharmaceutical company developing oral therapies that target the various phases of cell cycle control for the treatment of cancer and other serious diseases. Professor Sir David Lane, a recognized leader in the field of tumor suppressor biology, who discovered the p53 protein, founded the Company in 1996. In 1999, Cyclacel Pharmaceuticals was joined by Professor David Glover, a recognized leader in the mechanism of mitosis or cell division, who discovered, among other cell cycle targets, the mitotic kinases, Polo and Aurora, enzymes that act in the mitosis phase of the cell cycle.

Three product candidates are currently in clinical development. Sapacitabine (CYC682), a cell cycle modulating nucleoside analogue, is in Phase 3 development for the treatment of acute myeloid leukemia (AML) in the elderly under a Special Protocol Assessment agreement with the U.S. Food and Drug Administration and Phase 2 studies for myelodysplastic syndromes, lung cancer and chronic lymphocytic leukemia. Seliciclib (CYC202 or R-roscovitine), a CDK (cyclin dependent kinase) inhibitor, is in Phase 2 studies for the treatment of lung cancer and nasopharyngeal cancer and in a Phase 1 trial in combination with sapacitabine. CYC116, an Aurora kinase and VEGFR2 inhibitor, is in a Phase 1 trial in patients with solid tumors. Cyclacel Pharmaceuticals' strategy is to build a diversified biopharmaceutical business focused in hematology and oncology based on a portfolio of commercial products and a development pipeline of novel drug candidates.

Cyclacel Pharmaceuticals' ALIGN Pharmaceuticals subsidiary markets directly in the U.S. Xclair Cream for radiation dermatitis, Numoisyn® Liquid and Numoisyn® Lozenges for xerostomia.

After becoming the first European spin-out company to raise over $100 million in private equity, the company had to pull out of a stock market listing in July 2004. Cyclacel completed a reverse merger with Xcyte Therapies in December 2005 to acquire Nasdaq listing. This allowed Cyclacel to take advantage of its adopted Nasdaq listing by raising an additional $45 million in April 2006 through a private placement of stock and warrants.

Development.

News

Cyclacel Pharmaceuticals, Inc. -1.35% (healthcare)

Q reports

Period Date Adjusted Actuals EPS GAAP EPS
Q3 2020 2020-11-10 Future report Set alerts
Q2 2020 2020-08-12 0.00 0.00
Q1 2020 2020-05-12 -1.48 -1.40
Q4 2019 2020-02-26 -2.80 -2.80
Q3 2019 2019-11-13 -2.20 -2.20
Q2 2019 2019-08-13 -2.20 -2.20
Q1 2019 2019-05-14 -2.80 -2.80
Q4 2018 2019-03-27 -3.40 -3.40
Q3 2018 2018-11-12 -3.60 -3.60
Q2 2018 2018-08-09 -3.20 -3.20

Ratings

2015-10-16 Initiated Coverage HC Wainwright Buy $60.00
2014-12-17 Downgrade JMP Securities Outperform to Market Perform $108.00
2009-10-28 Initiated Merriman Buy
2008-08-12 Initiated Piper Jaffray Buy $5
2008-03-12 Reiterated Needham & Co Buy $12 to $7
2008-03-12 Reiterated Cantor Fitzgerald Buy $10.50 to $9
2007-11-27 Reiterated Cantor Fitzgerald Buy $14 to $10.50
2007-08-10 Reiterated Cantor Fitzgerald Buy $12 to $14
2007-06-04 Reiterated Needham & Co Buy $9 to $12
2007-04-23 Initiated Lazard Capital Buy $11
2007-04-10 Initiated Cantor Fitzgerald Buy $12
1970-01-01
2015-10-16 Initiated Coverage HC Wainwright Buy $60.00
2014-12-17 Downgrade JMP Securities Outperform to Market Perform $108.00
2009-10-28 Initiated Merriman Buy
2008-08-12 Initiated Piper Jaffray Buy $5
2008-03-12 Reiterated Needham & Co Buy $12 to $7

There is presents forecasts of rating agencies and recommendations for investors about this ticker

Major Shareholders

Name Relationship Total Shares Holding stocks
MARXE AUSTIN W & GREENHOUSE DAVID M 12.38%  (2806900) ADEP / ALCS / ASTC / ASYS / BTUI / BWEN / CACH / CDTI / CEVA / CLRX / CRMB / CYCC / DAEG / DOVR / ERI / ETRM / HEAR / INO / ISNS / ITI / LRAD / LTBR / MAG / MFI / OPXA / OVRL / PFSW / PLUG / PRKR / PTN / RGDX / RVLT / TGEN / URRE / VPCO / WPCS /
MORGAN STANLEY 10.04%  (2276852) CXDC / CYCC / EVV / HOLL / MS / TLP / TXI /
Eastern Capital LTD 9.56%  (2167261) ASTM / CYCC / CYTK / IBIO / PPHM /
Flynn James E Possible Member of 10% Group 3.89%  (881743) AAVL / ALIM / ASPX / ATRS / AUXL / AXGN / CASM / CYCC / DRNA / EHTH / EMAG / FIXX / HITK / LOXO / NURO / PRTO / REPH / RIGL / STRM / TRGT / TWTI / VNDA / XNPT /
TANG KEVIN C 2.47%  (559900) ARDM / CYCC / HRTX / LJPC / ODT / VNDA /
Rombotis Spiro George President & C.E.O. 1.06%  (241416) CYCC /
McBarron Paul E.V.P., Finance & C.O.O. 0.31%  (70096) CYCC /
Chiao Judy V.P., Clin. Dev. & Reg. Aff. 0.17%  (39024) CYCC /
Sems Lloyd 0.15%  (33333) CYCC / SLTC /
Sosnowski Robert Edward VP, Marketing & Sales 0.12%  (28000) CYCC /
BARKER SAM L 0.01%  (3100) CADX / CYCC / LXRX /

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