CafePress, Inc. is an American online retailer of stock and user-customized on demand products. The company was founded in San Mateo, California, but is now headquartered in Louisville, Kentucky, USA along with its production facility. In 2001, CafePress.com won the People's Voice Webby Award in the Commerce category.

CafePress.com sells T-shirts, bags, mugs, wall clocks, calendars, and a myriad of other products. Customers can upload their own graphics design, logo or text, which will be added to the product by CafePress. CafePress.com also offers print on demand services for wall art and stationery. The site also allows the user to have a virtual CafePress "shop" including an online storefront and website hosting, order management, fulfillment, payment processing, and customer service.

CafePress, Inc. was founded as a privately owned company in 1999 by Fred Durham and Maheesh Jain. As of February 2006, the site hosts over 2.6 million online shops with over 200 million products. As of March 2011, CafePress.com has more than 13 million members and over 325 million products are available on the site.

In July 2008, CafePress acquired the specialist photographic art printing business Imagekind, and in September 2010 acquired photo-to-canvas company Canvas On Demand to their platform of brands.

In June 2011, CafePress filed with the SEC to raise up to $80 million in an initial public offering.

On March 29, 2012, CafePress debuted at $19/share on the NASDAQ under ticker symbol PRSS. The stock hit an intra-day high of $22.69/share.

On April 30, 2012, CafePress announced that it would move its corporate headquarters to Louisville, Kentucky from San Mateo, California.

CafePress, Inc. has six primary brands: its flagship brand, CafePress.com, wholesale division CafePress Pro, Imagekind, Canvas On Demand, Great Big Canvas, and Canvas On Demand Pro. CafePress, Inc. also partners with other businesses to provide licensed content on their site, and power online custom shops for large companies, such as ABC, Urban Outfitters, and Peanuts Worldwide.